NEURON Note #29

Goals: Create a model for the transient voltage-gated sodium current (I_NaT) based on Dr. Park's data

Introduction:

A new I_NaT model is created based on Dr. Yul Young Park's experimental data.

Results:

Find parameters for the model

g = gbar * m³ * h

When finding the parameters, the GV curve is given more weight over time constants (gScale = 4).

		Activation (m)		Inactivation (h)
		Experiment	Model	Experiment	Model
Forward Rate	Constant		31.0		2.4
	vhalf (mv)		-5.6		-124.3
	k (mV)		-10.2		16.3
Backward Rate	Constant		11.3		2.4
	v1/2 (mv)		-65.8		-23.0
	k (mV)		21.4		-8.0
Properties	v1/2 (mv)	-21	-21.9	-56.3	-55.0
Properties	k (mV)	-6.3	-6.3	5.4	6.0

Normalized conductance, tau, and rate

Activation Rates

GV Curves

Activation	Inactivation	Deactivation
Simulation	Simulation	Simulation
Activation GV curve	Inactivation GV curve