NEURON Tutorial #15

Goals: Kinetic scheme (C <-> O)² - Find parameters for Ih

Specific Airms:

• Find the best fit for the kinetic scheme (C <-> O)²

Downloads:

• Main.hoc - Program start here.
• Boltzmann.hoc - For plotting Boltzmann equation.
• CO.hoc - Base on the kinetic scheme, plot the GV curve and the Tau-V curve, import experimental data, and find the best fit.
• MageeTau.dat - Experimental data deduced from Jeff Magee's paper (1998).

Steps:

Run "Main.hoc".
Click "Two states (C <-> O)²" button.
Click "Load exp. Tau data" button.
Select "MageeTau.dat" and click "OK".
Click "Find The Best Fit" button.

The Best Fit:

Alpha:
a = 0.1091
vhalf = -91.69 (mV)
k = 12.51 (mV)

Beta:
a = 0.09848
vhalf = -35.73 (mV)
k = -22.11 (mV)